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LiMa project

The current project has a main focus, to decipher new biomarkers and/or novel targets to prevent visceral white adipose tissue exhaustion; a critical step in the etiology of the disease characterized by metabolic dysfunction, low grade chronic inflammation, and tissue fibrosis. Aimed to identify the key metabolic pathways, metabolites and regulatory genes contributing to the re-establishment of whole-body glucose homeostasis and beta-cell function in an animal model of T2D before and after a lifestyle intervention program. Prevention of visceral adipose tissue exhaustion is a strategic therapeutic approach as an early or preventive treatment of obesity, with the aim to delay nonalcoholic fatty liver disease (NAFLD) progression and obesity associated pathologies.

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Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue

Metabolic plasticity is the ability of a biological system to adapt its metabolic phenotype to different environmental stressors...

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The role of skeletal muscle respiratory capacity in exercise performance

The connection between the respiratory capacity of skeletal muscle mitochondria and athletic performance is widely acknowledged in contemporary research

sandra-SkM.jpg

The role of skeletal muscle respiratory capacity in exercise performance

The connection between the respiratory capacity of skeletal muscle mitochondria and athletic performance is widely acknowledged in contemporary research

sandra-SkM.jpg

The role of skeletal muscle respiratory capacity in exercise performance

The connection between the respiratory capacity of skeletal muscle mitochondria and athletic performance is widely acknowledged in contemporary research

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